The following drugs belong to the bisphosphonate family:
- Actonel or Altevia (risedronate)
- Fosamax (alendronate)
- Boniva (ibandronate)
- Reclast or Zometa (zoledronic acid)
What is the safest bisphosphonate?
64–66,71,72 Recent publications indicate that the use of oral bisphosphonates (alendronate and risedronate) may be safe and effective in patients with glomerular filtration rates less than 30 mL/min.
What is an example of a bisphosphonate?
Bisphosponates such as risedronate (Actonel), alendronate (Fosamax), ibandronate (Boniva), zoledronic acid (Reclast), and pamidronate (Aredia) are used to treat and prevent osteoporosis—or, bone thinning—which occurs when the bones lose calcium and other minerals that help keep them strong and compact.
What are contraindications to bisphosphonates?
Contraindications to bisphosphonates include: History of hypersensitivity to the bisphosphonate. Hypocalcemia. Chronic kidney disease with a glomerular filtration rate of less than 30 to 35 mL/min.
Which is the best bisphosphonate?
Oral – We suggest alendronate or risedronate as the initial choice of oral bisphosphonate (table 1). We most commonly use alendronate, in part due to direct evidence showing residual fracture benefit in selected patients after completing a five-year course of therapy [1].
Is raloxifene a bisphosphonate?
The bisphosphonate alendronate and the selective estrogen receptor modulator (SERM) raloxifene are among the most popular antiresorptive agents for the prevention and treatment of postmenopausal osteoporosis6,7.
Which bisphosphonate is best tolerated?
We suggest either alendronate or risedronate as the initial choice of bisphosphonate (Grade 2B). Individuals with well-controlled gastroesophageal reflux or peptic ulcer disease can also take alendronate or risedronate.
Who should not take Prolia?
People with weakened immune systems are advised not to use to denosumab because it can lead to serious infections that require hospitalization (such as heart infections). It can also cause disintegration of the jaw, called osteonecrosis, and atypical femur fractures.
Is Evista a bisphosphonate?
Fosamax and Evista belong to different drug classes. Fosamax is a bisphosphonate and Evista is an estrogen agonist/antagonist.
What are the two main adverse effects of bisphosphonates?
General side effects of bisphosphonates and denosumab
- Fever and flu-like symptoms.
- Low levels of calcium in your blood (hypocalcaemia)
- Bone and joint pain.
- Changes in bowel movements.
- Tiredness and low energy levels.
- Feeling sick.
- Changes to your kidneys.
- Irritation of the food pipe (oesophagus)
What drugs increase bone density?
Fosamax and other drugs such as Actonel, Boniva, and Reclast increase bone density and help prevent and treat osteoporosis and/or reduce the risk of fractures.
What is the newest osteoporosis drug?
Romosozumab (Evenity). This is the newest bone-building medication to treat osteoporosis.
What are bisphosphonates used to treat?
Bisphosphonates are used in the treatment of osteoporosis, Paget’s disease of bone, and may be used to lower high calcium levels in people with cancer.
Are there any risks in taking bisphosphonates?
However, the evidence is mixed and in most situations, the benefits of treatment are greater than any potential risk. Some people taking bisphosphonates have developed painful, partial or complete fractures in the upper, outer region of the thigh bone (femur) below the hip.
What is the optimal duration of bisphosphonate treatment for osteoporosis?
The optimal duration of bisphosphonate treatment for osteoporosis is unknown. Bisphosphonate medications approved for the prevention and/or treatment of osteoporosis have clinical trial data supporting fracture reduction efficacy through at least 3 years of treatment and, in some cases, through 5 years.
Do bisphosphonates for osteoporosis cause fractures of the thigh?
[10-13-2010] The U.S. Food and Drug Administration (FDA) is updating the public regarding information previously communicated describing the risk of atypical fractures of the thigh, known as subtrochanteric and diaphyseal femur fractures, in patients who take bisphosphonates for osteoporosis.
