Where is the SOX2 gene found?

What is the function of SOX2?

The SOX2 gene provides instructions for making a protein that plays a critical role in the formation of many different tissues and organs during embryonic development. The SOX2 protein is especially important for the development of the eyes.

How is SOX2 regulated?

Expression and function of SOX2 is regulated through several post-translational modifications such as ubiquitination, sumoylation, phosphorylation, methylation and acetylation.

What is SOX2 marker?

SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev Neurosci.

What is the source of the name nanog?

The name NANOG derives from Tìr nan Òg, the mythical Celtic land of youth. The NANOG protein possesses a homeobox sequence, containing a 60-63 amino acid motif, within the coded protein.

Is Sox2 nuclear?

We have identified K75 as an acetylation site in the nuclear export signal of Sox2 and demonstrated its role in Sox2 cellular localization and biological activity during ES cell differentiation.

What activates Sox2?

In melanoma cells, epidermal growth factor receptor (EGFR) activation enhances STAT3 nuclear translocation and binding to the SOX2 promoter, leading to increased SOX2 expression to facilitate cell survival and self-renewal.

What is the gene NANOG?

NANOG (Nanog Homeobox) is a Protein Coding gene. Diseases associated with NANOG include Teratocarcinoma and Germ Cell And Embryonal Cancer. Among its related pathways are Mesodermal Commitment Pathway and Oct4 in Mammalian ESC Pluripotency.

What is the significance of NANOG?

NANOG protein expression is a biomarker that indicates poor clinical outcome in lung, breast, gastric, colorectal, pancreatic, and ovarian cancer as well as in hepatocellular, oral squamous cell, esophageal, and nasopharyngeal carcinoma.

What do you mean by pluripotency?

Definition. Pluripotency describes the ability of a cell to develop into the three primary germ cell layers of the early embryo and therefore into all cells of the adult body, but not extra-embryonic tissues such as the placenta.

What is the source of the name NANOG?

Where does the name NANOG come from?

Nanog, named after the fountain of eternal youth, is considered the key to pluripotency, but its role is puzzling: it can be deleted from embryonic stem cells without causing them to differentiate, and it is not among the collection of genes that can induce specialized cells to become pluripotent.

Is SOX2 promoter methylation a biomarker for air pollution exposure?

Results find that SOX2 was significantly hypermethylated in both men and women residing in Taiwan. The consistency in the findings for both sexes shows that SOX2 promoter methylation could serve as a potential biomarker for industrial air pollution exposure.

What does Sox2 stand for?

SOX2 (SRY-Box Transcription Factor 2) is a Protein Coding gene. Diseases associated with SOX2 include Microphthalmia, Syndromic 3 and Septooptic Dysplasia. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Signaling by GPCR.

What is the function of the sox2 gene?

Entrez Gene Summary for SOX2 Gene. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation.

What is the role of Sox2 in pluripotency pathway?

Oct-4, Sox2 and Nanog positively regulate transcription of all pluripotency circuitry proteins in the LIF pathway. NPM1, a transcriptional regulator involved in cell proliferation, individually forms complexes with Sox2, Oct4 and Nanog in embryonic stem cells.