The term uveoscleral outflow refers to the drainage of ocular aqueous humor from the anterior chamber into the anterior chamber angle other than through the trabecular meshwork (Figure). Unlike the trabecular outflow route, the uveoscleral outflow route is not a distinctive pathway with tubes and channels.
What is trabecular outflow?
The trabecular outflow pathway is the primary draining tissue for the aqueous humor in the eye. It consists of 3 structures, the trabecular meshwork (TM), juxtacanalicular tissue, and Schlemm’s canal. In a healthy eye, IOP is maintained within a narrow range through dynamic regulation of trabecular outflow resistance.
What is the main outflow facility of the eye?
The outflow facilities are a complex hydraulic system that allows the AH to exit the eye consistently, yet maintaining a physiologic IOP balanced with aqueous secretion. When the regulation of the outflow is impaired, an increase in IOP occurs.
Where does aqueous humor drain into?
Schlemm’s canal
The aqueous humor travels around the lens, through the pupil, bathes the back of the cornea, and drains into Schlemm’s canal through the trabecular meshwork.
How do you increase Uveoscleral outflow?
The uveoscleral outflow is decreased by contraction (pilocarpine) and increased by relaxation (atropine) of the ciliary muscle. Thus, changing the tone of the ciliary muscle may redistribute aqueous humour between the conventional and uveoscleral outflow routes.
How does Latanoprost increase Uveoscleral outflow?
The known effect of Latanoprost increase uveoscleral outflow by remodeling extracellular matrix and widening intermuscular spaces in the ciliary body may not detected by pneumotonography after 2 weeks of treatment.
What are the two natural aqueous outflow pathways?
Aqueous humor outflow occurs through two routes, the conventional and uveoscleral pathways.
Does pilocarpine increase Uveoscleral outflow?
How is aqueous produced?
Aqueous humor is produced by the ciliary body, in uveoscleral route, it flows from the posterior chamber through the pupil into the anterior chamber and then (shown by dashed lines and arrowheads) through the face of the ciliary body and iris root to the ciliary muscle and suprachoroidal space to either veins in the …
What is the function of trabecular meshwork?
The trabecular meshwork is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber (the chamber on the front of the eye covered by the cornea).
What are the three main functions of aqueous humor?
What is the function of Aqueous Humor?
- Transports vitamin C in the front segment to act as an antioxidant agent.
- Provides inflation for expansion of the cornea (increasing protection against dust, grains, wind, pollen and a number of pathogens)
- Maintains intraocular pressure.
What would happen if you were to lose your aqueous humor?
Aqueous humor, which is the fluid that flows into your eye, is constantly cycling within your eyes. It should flow out of your eyes and through the drainage angle. When there is a disruption in this process, pressure will build and if left untreated, the loss of vision may occur.
What is the uveoscleral outflow route?
Unlike the trabecular outflow route, the uveoscleral outflow route is not a distinctive pathway with tubes and channels. Rather, it is a route whereby aqueous humor seeps through, around, and between tissues, including the supraciliary space, ciliary muscle, suprachoroidal space, choroidal vessels, emissarial canals, sclera, and lymphatic vessels.
What is the unconventional outflow pathway?
Rather, it is a route whereby aqueous humor seeps through, around, and between tissues, including the supraciliary space, ciliary muscle, suprachoroidal space, choroidal vessels, emissarial canals, sclera, and lymphatic vessels. The lack of a well-defined structural pathway has given this route the label unconventional outflow pathway.
How do you calculate uveoscleral outflow in Goldmann equation?
To account for uveoscleral outflow, a modified Goldmann equation can be formulated where the variable F of the basic equation is expanded to include uveoscleral outflow ( Fu ). Thus, the Goldmann equation is re-expressed as IOP = ( Fin – Fu ) ( R) + EVP. 14
Is uveoscleral outflow pressure dependent or pressure independent?
Trabecular outflow is said to be pressure-dependent as it occurs down a pressure gradient (increased outflow with increased IOP), but uveoscleral outflow is considered to be pressure-independent, being little influenced by IOP in a typical physiological range.
