Common side effects may include:
- dizziness;
- nausea, stomach pain, constipation;
- skin rash or other irritation;
- sleep problems (insomnia); or.
- mouth sores or ulcers, pain with swallowing (while using selegiline orally disintegrating tablets).
What should I monitor with selegiline?
Blood pressure monitoring is necessary for patients taking selegiline to decrease falls associated with orthostatic hypotension and prevent hypertensive crisis and long-term effects of elevated blood pressure. Patients require monitoring for symptoms of Parkinsonism and serotonin syndrome.
What drugs should not be taken with selegiline?
Do not take selegiline if you have used narcotic pain medicines (including meperidine, methadone, tramadol, Demerol®, Dolophine®, Ultram®) or an MAO inhibitor (MAOI) (eg, isocarboxazid, linezolid, phenelzine, tranylcypromine, Marplan®, Nardil®, Parnate®, Zyvox®) within the past 14 days.
Which behavior should be avoided by a patient who is taking selegiline?
Do not swallow the ODT tablet. The patient should avoid ingesting food or liquids for 5 minutes before and after taking selegiline ODT. Do not administer doses greater than 2.5 mg/day because of the risk of hypertensive crisis.
Is selegiline used for depression?
Transdermal selegiline, an irreversible selective monoamine oxidase B (MAO-B) inhibitor, is approved as an antidepressant in the USA. Some reports have shown that oral selegiline treatment can also be effective in treating depression.
What are the benefits of selegiline?
Selegiline is used to help control the symptoms of Parkinson’s disease (PD; a disorder of the nervous system that causes difficulties with movement, muscle control, and balance) in people who are taking levodopa and carbidopa combination (Sinemet).
What drugs interact with selegiline?
Some products that may interact with selegiline include: antidepressants (including bupropion, maprotiline, mirtazapine), other MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, tranylcypromine), appetite suppressants (such as …
Does selegiline increase serotonin?
In larger doses (more than 20 mg/day), it loses its specificity for MAO-B and also inhibits MAO-A, which increases serotonin and norepinephrine levels in the brain.
Does selegiline help with sleep?
In conclusion, selegiline alleviates both main symptoms of narcolepsy-the abnormal sleep tendency and cataplexy. Thus, treatment with selegiline makes it possible to avoid polypharmacy and to use a potent stimulant without known addiction risk.
Can selegiline be taken at night?
It is best to take the capsules or tablets in the morning during breakfast and lunch. You should not use it with dinner because you may have trouble sleeping.
Does selegiline increase dopamine?
Selegiline is in a group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.
How does selegiline make you feel?
SIDE EFFECTS: Dizziness, abdominal pain, dry mouth, nausea, stomach upset, trouble sleeping, and headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. If you are also taking levodopa, you may experience more side effects from the levodopa when taking selegiline.
What are the side effects of selegiline tablets?
Talk with your doctor if this occurs. Common side effects may include: dizziness; nausea, stomach pain, constipation; skin rash or other irritation; sleep problems (insomnia); or. mouth sores or ulcers, pain with swallowing (while using selegiline orally disintegrating tablets).
Can selegiline and pethidine be taken together?
Selegiline in combination with the opioid analgesic pethidine is not recommended, as it can lead to severe adverse effects. Several other synthetic opioids such as tramadol and methadone, as well as various triptans, are contraindicated due to potential for serotonin syndrome.
What should I do if I am taking selegiline and levodopa?
If any of these effects persist or worsen, notify your doctor or pharmacist promptly. If you are also taking levodopa, you may experience more side effects from the levodopa when taking selegiline.
Can you eat tyramine while taking selegiline?
Eating tyramine while you are using selegiline can raise your blood pressure to dangerous levels which could cause life-threatening side effects. You should become very familiar with the list of foods to avoid while you are using selegiline. Selegiline may impair your thinking or reactions.
